Tailored Therapies And DNA Tools: Oligonucleotide Synthesis Market Outlook

Published: 2025-05-05
Views: 11
Author: Shitalmax
Published in: Business

The global Oligonucleotide Synthesis Market Size is poised for significant growth, projected to reach USD 17.43 billion by 2030, expanding at a robust CAGR of 14.87% from its 2023 valuation of USD 6.60 billion. This surge is attributed to the escalating demand for personalized medicine, advancements in genetic research, and the increasing utilization of oligonucleotides in diagnostics and therapeutics.

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Market Definition and Scope

Oligonucleotide synthesis involves the chemical creation of short DNA or RNA sequences, known as oligonucleotides. These sequences are pivotal in various applications, including genetic testing, research, forensic analysis, and the development of novel therapeutics. The market encompasses products and services such as synthesized oligonucleotides, equipment/synthesizers, reagents, and custom synthesis services.

Key Growth Drivers and Opportunities

1. Personalized Medicine and Genetic Research: The shift towards personalized healthcare has amplified the need for custom oligonucleotides in diagnostics and targeted therapies. Their role in gene expression modulation and as antisense therapeutics is central to this trend.

2. Technological Advancements: Innovations in synthesis technologies, including solid-phase and enzymatic methods, have enhanced the efficiency and scalability of oligonucleotide production, meeting the growing demands of research and clinical applications.

3. Increased R&D Investments: Emerging economies are witnessing substantial investments in biotechnology. For instance, Merck KGaA invested USD 76 million to expand its high-purity reagents production in China, while Insud Pharma inaugurated an oligonucleotide manufacturing unit in India focusing on treatments for spinal muscular atrophy. 

4. Rising Prevalence of Chronic Diseases: The global increase in chronic conditions such as cancer and genetic disorders has propelled the demand for advanced diagnostic tools and targeted therapies, wherein oligonucleotides play a crucial role.

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Descriptive Market Segmentation

By Product & Services:

• Oligonucleotides:

  • DNA: Includes column-based and array-based synthesis methods.

  • RNA: Encompasses short RNA oligos (<65 nucleotides), long RNA oligos (>65 nucleotides), and CRISPR single-guide RNAs (sgRNAs).

• Equipment/Synthesizers: Instruments utilized for the automated synthesis of oligonucleotides.

• Reagents: Chemical substances required for the synthesis process.

• Services:

  • Custom Synthesis: Tailored oligonucleotide sequences produced in varying scales (e.g., 25 nmol to 10,000 nmol).

  • Modification Services: Chemical alterations to enhance stability or functionality.

  • Purification Services: Processes to ensure the purity and quality of synthesized oligonucleotides. 

By Application:

• PCR Primers: Essential for amplifying specific DNA sequences in research and diagnostics.

• PCR Assays & Panels: Utilized in detecting and quantifying nucleic acids.

• Sequencing: Critical in genomics for determining nucleotide sequences.

• DNA Microarrays: Used for gene expression profiling and genotyping.

• Fluorescence In Situ Hybridization (FISH): A technique for detecting and localizing specific DNA sequences on chromosomes.

• Antisense Oligonucleotides: Employed in therapeutics to inhibit gene expression.

Country-Level Analysis

United States:

The U.S. remains at the forefront of the oligonucleotide synthesis market, driven by a robust biotechnology sector, substantial R&D investments, and a favorable regulatory environment. In 2023, North America accounted for 40.15% of the global market share, with the U.S. leading in revenue generation. 

Germany:

Germany's market is experiencing significant growth, projected to reach USD 611.4 million by 2030, growing at a CAGR of 13.9% from 2025. The country's strong healthcare infrastructure, coupled with government initiatives like “Industrie 4.0,” supports advancements in biotechnology and personalized medicine. 

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Competitive Landscape

The oligonucleotide synthesis market is characterized by the presence of several key players who are focusing on strategic collaborations, acquisitions, and technological innovations to strengthen their market position.

Thermo Fisher Scientific Inc.: A leading provider of analytical instruments, equipment, reagents, and consumables.

• Merck KGaA: Investing in expanding its production capabilities for high-purity reagents, particularly in emerging markets.

• Danaher Corporation: Through its subsidiary Integrated DNA Technologies (IDT), it offers a wide range of custom nucleic acid products.

• Agilent Technologies: Provides instruments, software, services, and consumables for laboratory workflows.

• Twist Bioscience Corporation: Specializes in synthetic DNA manufacturing for various applications.

Notably, in June 2024, GSK acquired Elsie Biotechnologies for up to USD 50 million to enhance its oligonucleotide platform, underscoring the strategic importance of oligonucleotide technologies in pharmaceutical development.

Reasons to Buy

• Access data-driven insights to inform investment and development strategies
• Understand competitive positioning across regions
• Discover emerging opportunities in key application segments
• Stay ahead with accurate forecasts and trend analysis

Key Highlights:

• Historical Market Data (2018-2023)
• Forecasts by Segment, Region, and Industry Application (2024-2030)
• SWOT Analysis, Value Chain Insights, and Growth Drivers
• Legal Aspects by Region and Emerging Opportunities

Top Questions Answered:

• What are the key growth drivers and trends in the market?
• Who are the major players, and how do they maintain a competitive edge?
• What new applications are poised to revolutionize the Oligonucleotide Synthesis industry?
• How will the market grow in the coming years, and at what rate?

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